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| 货号 | RC0191 |
| 说明书 | |
| CAS号 | 10417-94-4 |
| 分子式 | C20H30O2 |
| 分子量 | 302.45 |
| 产品描述 | |
| 描述 | Eicosa-5Z,8Z,11Z,14Z,17Z-pentaenoic Acid (EPA), an ω-3 fatty acid, has been reported to act as a precursor to thromboxanes and prostaglandins (PG). EPA inhibits amino acid oxygenation by PG endoperoxide H synthase-1 and 5-LO (5-lipoxygenase). Experiments have demonstrated the ability of EPA to increase Cafestol palmitate incorporation into the lipid fraction and decrease the rate of fatty acid oxidation in murine adipose tissue. Additionally, this agent has demonstrated the ability to cause a decrease in gene expression for IL-6 and TNF-α both in skeletal muscle and adipose tissue. |
| 应用 | A 5-LO inhibitor |
| 纯度 | 95% |
| 储存/保存方法 | Store at -20° C，2 years |
| 形态 | Liquid |
| 基本信息 | |
| 别名 | Timnodonic acid |
| 外观 | Oil |
| 密度 | ~0.9 g/mL (Predicted) |
| 熔点 | -54--53° C (lit.) |
| 沸点 | ~439.30° C at 760 mmHg (Predicted) |
| 折射率 | n20D 1.50 (lit.) |
| IC50 | mPGES1: IC50 = 300 nM; Cyclooxygenase-2: IC50 = 7100 nM (Ovis aries) |
| PK值 | pKa: 4.75 |
| 可溶性/溶解性 | Soluble in ethanol (~100 mg/ml), DMSO (~100 mg/ml), DMF (~100 mg/ml), chloroform, ethyl acetate, and methanol. |
| MDL | MFCD00065716 |
| PubChem CID | 446284 |
| Beilstein 注册 | 1714433 |
| EC号码 | 600-528-7 |
| 温馨提示：本产品仅作科研实验使用，不支持临床等研究 | |
